Project Details
Description
This is a collaborative project between our laboratory at the Center for primary health care research and the Department of medicine Skåne university hospital (SUS).
Abdominal aortic aneurysm (AAA) is a serious disease in which aortic dilatation may progress to rupture with a mortality rate of over 80 percent. Insufficient knowledge of AAA pathophysiology makes it difficult to develop specific diagnostic-prognostic tools and therapies. Oxidative stress (over-production of free radicals) has been implicated in various cardiovascular diseases; however, it is still not well-characterized in AAA.
Through our published and preliminary research, we have identified factors in AAA related to oxidative stress. In this study, by using high-throughput and functional approaches, along with well-defined clinical cohorts, we investigate these candidate factors and their interaction(s) in AAA risk and growth. Endogenous and exogenous factors contributing to oxidative stress are mostly modifiable, an in-depth disease-specific characterization of these factors has a potential for tailored clinical translation.
Our goal is to develop an integrative model combing genetic, environmental and clinical factors for risk stratification to guide improved screening and follow-up strategies for AAA.
Abdominal aortic aneurysm (AAA) is a serious disease in which aortic dilatation may progress to rupture with a mortality rate of over 80 percent. Insufficient knowledge of AAA pathophysiology makes it difficult to develop specific diagnostic-prognostic tools and therapies. Oxidative stress (over-production of free radicals) has been implicated in various cardiovascular diseases; however, it is still not well-characterized in AAA.
Through our published and preliminary research, we have identified factors in AAA related to oxidative stress. In this study, by using high-throughput and functional approaches, along with well-defined clinical cohorts, we investigate these candidate factors and their interaction(s) in AAA risk and growth. Endogenous and exogenous factors contributing to oxidative stress are mostly modifiable, an in-depth disease-specific characterization of these factors has a potential for tailored clinical translation.
Our goal is to develop an integrative model combing genetic, environmental and clinical factors for risk stratification to guide improved screening and follow-up strategies for AAA.
Status | Active |
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Effective start/end date | 2017/11/01 → … |