Genomisk karakterisering av trippelnegativ bröstcancer (TNBC)

Research output

Research output per year 2016 2017 2019 2019

• 7 Article

Research output per year

Research output per year

Search results

• 2019

  Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series

  Vallon-Christersson, J., Häkkinen, J., Hegardt, C., Saal, L., Larsson, C., Ehinger, A., Lindman, H., Olofsson, H., Sjoblom, T., Wärnberg, F., Rydén, L., Loman, N., Malmberg, M., Borg, Å. & Staaf, J., 2019 Aug 21, In: Scientific Reports. 9, 12184.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Breast Cancer 100%
  • Gene Signature 100%
  • Therapeutic Procedure 66%
  • Disease 50%

• Prediction of lymph node metastasis in breast cancer by gene expression and clinicopathological models: Development and validation within a population based cohort.

  Dihge, L., Vallon-Christersson, J., Hegardt, C., Saal, L., Häkkinen, J., Larsson, C., Ehinger, A., Loman, N., Malmberg, M., Bendahl, P.-O., Borg, Å., Staaf, J. & Rydén, L., 2019 Jul 24, In: Clinical Cancer Research. 25, 21, p. 6368-6381

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Development 100%
  • Breast Cancer 100%
  • Lymph Node Metastasis 100%
  • Metastasis 100%

• Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study

  Staaf, J., Glodzik, D., Bosch, A., Vallon-Christersson, J., Reuterswärd, C., Häkkinen, J., Degasperi, A., Amarante, T. D., Saal, L. H., Hegardt, C., Stobart, H., Ehinger, A., Larsson, C., Rydén, L., Loman, N., Malmberg, M., Kvist, A., Ehrencrona, H., Davies, H. R. & Borg, Å. & 1 others, Nik-Zainal, S., 2019, In: Nature Medicine. 25, p. 1526–1533

  Research output: Contribution to journal › Article › peer-review

  • Clinical Study 100%
  • BRCA1 75%
  • Germ Cell 50%
  • Germline 50%
  • Genetics 25%
• 2018

  Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers

  Glodzik, D., Purdie, C. A., Rye, I. H., Simpson, P. T., Staaf, J., Span, P. N., Russnes, H. & Nik-Zainal, S., 2018 Sept 15, In: Annals of Oncology. 30252041.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncogene 100%
  • Amplicon 33%
  • MCL1 33%
• 2017

  HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

  Davies, H. R., Glodzik, D., Morganella, S., Yates, L. R., Staaf, J., Zou, X., Ramakrishna, M., Martin, S., Boyault, S., Sieuwerts, A. M., Simpson, P. T., King, T. A., Raine, K., Eyfjord, J. E., Kong, G., Borg, Å., Birney, E., Stunnenberg, H. G., van de Vijver, M. J. & Børresen-Dale, A.-L. & 13 others, Martens, J. W. M., Span, P. N., Lakhani, S. R., Vincent-Salomon, A., Sotiriou, C., Tutt, A., Thompson, A. M., Van Laere, S., Richardson, A. L., Viari, A., Campbell, P. J., Stratton, M. R. & Nik-Zainal, S., 2017 Apr, In: Nature Medicine. 23, 4, p. 517-525 9 p.

  Research output: Contribution to journal › Article › peer-review

  • BRCA1 100%
  • BRCA2 100%
  • Poly ADP Ribose Polymerase 23%
  • Germ Cell 15%
  • Germline 15%

• A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

  Glodzik, D., Morganella, S., Davies, H. R., Simpson, P. T., Li, Y., Zou, X., Diez-Perez, J., Staaf, J., Alexandrov, L. B., Smid, M., Brinkman, A. B., Rye, I. H., Russnes, H., Raine, K., Purdie, C. A., Lakhani, S. R., Thompson, A. M., Birney, E., Stunnenberg, H. G. & van de Vijver, M. J. & 10 others, Martens, J. W. M., Børresen-Dale, A.-L., Richardson, A. L., Kong, G., Viari, A., Easton, D., Evan, G., Campbell, P. J., Stratton, M. R. & Nik-Zainal, S., 2017 Mar 1, In: Nature Genetics. 49, 3, p. 341-348 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Regulatory Element 100%
  • Germ Cell 100%
  • Germline 100%
  • Breast Cancer 100%
  • Somatics 100%
• 2016

  Landscape of somatic mutations in 560 breast cancer whole-genome sequences

  Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M. & Ahn, S.-M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H.-Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J.-Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., van't Veer, L., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., van de Vijver, M. J., Martens, J. W. M., Børresen-Dale, A.-L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 2016 Jun 2, In: Nature. 534, 7605, p. 47-54 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Somatic Mutation 100%
  • BRCA1 66%
  • Oncogene 66%
  • Mutation Rate 66%
  • Genetics 33%