Project Details
Description
This project concerns how the immune system affects and is affected by metastatic breast cancer. The aim is that the results generated from this research plan could be used to better understand cancer, hopefully leading to novel or improved cancer treatment strategies.
It is known today that the immune system can detect breast cancer cells, but for unclear reasons this leads to a suppressed immune response instead. We investigate whether breast cancer lymph node metastasis affects the local activation of anti-tumor immune responses in the affected lymph node and whether this may be one of the reasons to why the immune system is ineffective in targeting breast cancer. A common molecular connection between the tolerant and hence silenced immune response and the dormant and hence surviving cancer cells is also investigated.
The goal with this project is to be able to understand why the innate immune system is so poor in activating the adaptive immune system against breast cancer, to make it possible for the future to activate the immune response against the cancer cells. Understanding what is causing the immunosuppression and novel ways of revoking this condition is of large relevance.
It is known today that the immune system can detect breast cancer cells, but for unclear reasons this leads to a suppressed immune response instead. We investigate whether breast cancer lymph node metastasis affects the local activation of anti-tumor immune responses in the affected lymph node and whether this may be one of the reasons to why the immune system is ineffective in targeting breast cancer. A common molecular connection between the tolerant and hence silenced immune response and the dormant and hence surviving cancer cells is also investigated.
The goal with this project is to be able to understand why the innate immune system is so poor in activating the adaptive immune system against breast cancer, to make it possible for the future to activate the immune response against the cancer cells. Understanding what is causing the immunosuppression and novel ways of revoking this condition is of large relevance.
| Status | Active |
|---|---|
| Effective start/end date | 2024/01/01 → 2028/12/31 |
Funding
- UMAS Cancerstiftelse - Allmänna Sjukhusets i Malmö Stiftelse för bekämpande av Cancer
- Cancerfonden
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Subject classification (UKÄ)
- Cancer and Oncology