inflammatory events leading to autoimmune Diabetes

Project: Research

Project Details

Description

Here we investigate inflammatory events initiating the development of type-1 diabetes and cellular events promoting disease progression. Therefore we have recently established that transplantation of pancreatic islets to the ACE and longitudinally imaging by 2-Photon microscopy can be used to follow the migration of single cells in islet grafts (Schmidt-Christensen et al., Diabetologia 2013). Together with Theo Lasser ´s group at EPFL in Lausanne we describe a further developed labelfree technique (Berclaz et. al, Diabetologia 2016). By introducing a novel label-free approach, it is now possible to visualize and follow the same mouse and human islets of Langerhans, their structure and early indicators of disease progression like inflammation and changing vasculature repeatedly and over a long period of time.
StatusFinished
Effective start/end date2009/10/012020/07/31

Collaborative partners

Funding

  • The Royal Physiographic Society in Lund

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being