Investigation of mitochondrial function in blood cells from patients with chronic neurodegenerative or muscular disorders

Project: Research

Project Details

Description

Mitochondrial dysfunction is implicated in several chronic neurodegenerative disorders, such as Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS) and Alzheimer's Dementia (AD) and also in patients with certain muscular disorders.
The aim of the study is to determine if defects in mitochondrial function can be detected in peripheral blood cells (platelets and white blood cells) derived from patients with chronic neurodegenerative or muscular disorders using high-resolution respirometry.
Some degree of mitochondrial involvement in the pathogenesis of all these diseases have been suggested but the exact role of the mitochondria in neurodegeneration remains to be elucidated.
AcronymMIND
StatusActive
Effective start/end date2011/05/02 → …

UKÄ subject classification

  • Neurology
  • Cell and Molecular Biology
  • Biomedical Laboratory Science/Technology

Keywords

  • mitochondria
  • blood cells
  • neurodegeneration
  • Parkinson's disease
  • high-resolution respirometry
  • ALS
  • muscular disorders