Joint outcome of prophylactic treatment of haemophilia in Sweden evaluated by Magnetic Resonance Imaging (MRI)

This is an observational, descriptive outcome study. The primary outcome measure is the MRI-score (four joints, (ancles, knees) and worst joint), and the secondary outcome measure is the physical haemophilia joint score. Determinants are mode of treatment, age, number of joint haemorrhages and physical activity. Participating centers: Three treatment centers, Malmö, Stockholm and Göteborg, and 2 MRI departments (Malmö, Stockholm). Every patient in Sweden who is born between 1980 and 1999 and has severe or moderate hemophilia A or B will be offered to participate (approximately 120 patients)

The general aim of this project is to improve prophylactic treatment of hemophilia by evaluation of joint status.

Specific aims
- To determine, by use of MRI, the joint outcome of prophylactic treatment using the Swedish model
- To study the evolution on MRI of joint changes by age in young individuals with severe and moderate haemophilia
- To determine the joint outcome in patients with moderate hemophilia treated without prophylaxis in comparison to age-matched patients with severe hemophilia on prophylaxis
- To study the correlation of the MRI score and the physical ‘Hemophilia Health Joint Score’ and the number of joint bleeds.
- To study the value of MRI scoring for assessment of the severity of joint changes in hemophiliacs.