Lipidomics in the Placenta after High Exposure to PFAS

The “promotion of healthy lives and well-being” is a United Nations Agenda 2030 goal to which Sweden is highly committed. This includes reducing premature mortality from non-communicable diseases and deaths linked to hazardous chemicals by one-third by 2030. Cardiovascular diseases (CVDs) are a leading cause of death globally and in Sweden, with chemical exposures, such as PFAS (per- and polyfluoroalkyl substances), potentially contributing to early-onset CVDs. PFAS can disrupt placental function, hormone balance, and lipid metabolism during pregnancy, possibly leading to long-term liver and cardiovascular adverse effects.
In Ronneby, Sweden, decades of PFAS exposure through contaminated drinking water have raised concerns about health impacts. To investigate, the Ronneby Mother-Child Cohort (RMCC) was established and placental samples from 177 participants were obtained. LIPHES will assess the effects of PFAS on lipid metabolism and the thyroid hormone system, providing insights to inform public health policies and action plans for PFAS-contaminated areas.