Lobular cancer

Ductal cancer is the, by far, most common histological subtype, constituting between 80 and 85% of all breast cancers. Lobular breast cancer is the second most common subtype (10-15%). Biomarkers are usually evaluated in materials consisting of mixed histological subtypes, and the results therefore reflect mainly their importance in ductal cancer. It is important to evaluate the prognostic and predictive importance of biomarkers in the different histological subtypes, separately. In the current project we are evaluating the prognostic importance of new putative prognostic biomarkers (e.g. AIB1, ERbeta, GPER1, bcl2) in a cohort consisting of more than 200 patients with lobular breast cancer and with a long clinical follow-up (>20 years).