Research output per year
Research output per year
Project Details
Description
We aim to identify novel interventions for prevention and treatment of diabetes-related cardiovascular disease (CVD). Our strategy is to identify genetic, endocrine and metabolic disturbances in humans which are causally related to disease development and are detectable many years before disease presents. We then test in both animals and in human intervention studies if manipulation of such molecular disturbances ameliorate cardiometabolic risk.
A few examples of our translational research achievements include discovery of: (1) CVD genetic risk variants which identify “hidden high-risk individuals” in the population and specific pharmacological and life-style treatments which can revert that genetic risk, (2) neurotensin as a key hormone linking hyper-efficient intestinal fat absorption and storage to obesity, diabetes and CVD development and (3) high vasopressin secretion as a cause of diabetes and CVD and the potential of increased water intake to revert the risk.
A few examples of our translational research achievements include discovery of: (1) CVD genetic risk variants which identify “hidden high-risk individuals” in the population and specific pharmacological and life-style treatments which can revert that genetic risk, (2) neurotensin as a key hormone linking hyper-efficient intestinal fat absorption and storage to obesity, diabetes and CVD development and (3) high vasopressin secretion as a cause of diabetes and CVD and the potential of increased water intake to revert the risk.
| Short title | Novel Ways to Prevent Cardiometabolic Disease |
|---|---|
| Acronym | PREVENT-2024 |
| Status | Active |
| Effective start/end date | 2021/01/01 → 2025/12/31 |
Funding
- European Commission - Horizon 2020
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Research output
- 25 Article
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Associations between biomarkers of multimorbidity burden and mortality risk among patients with acute dyspnea
Wessman, T., Tofik, R., Ruge, T. & Melander, O., 2022, In: Internal and Emergency Medicine. 17, 2, p. 559-567Research output: Contribution to journal › Article › peer-review
Open Access -
Bioactive adrenomedullin a prognostic biomarker in patients with mild to moderate dyspnea at the emergency department: an observational study
Bronton, K., Wessman, T., Gränsbo, K., Schulte, J., Hartmann, O. & Melander, O., 2022, In: Internal and Emergency Medicine. 17, 2, p. 541-550Research output: Contribution to journal › Article › peer-review
Open Access -
Self-care Management Intervention in Heart Failure (SMART-HF): A Multicenter Randomized Controlled Trial
Sahlin, D., REZANEZAD, B., EDVINSSON, M. L., BACHUS, E., MELANDER, O. & GERWARD, S., 2022, In: Journal of Cardiac Failure. 28, 1, p. 3-12Research output: Contribution to journal › Article › peer-review
Open Access