Myocardial Infarction with Non-obstructive Coronary Arteries

Project: Dissertation

Project Details


Myocardial infarction (AMI) is traditionally associated with coronary obstruction developing from coronary artery disease (CAD). Two main therapeutic approaches to CAD were established many years ago, coronary
by-pass surgery (CABG) in 1960s and percutaneous coronary interventions (PCI) in 1970s, both with great success.
Now, with the advent of more specific tests for myocardial damage, such as high-sensitivity troponin, the term "myocardial infarction" has been extended to various clinical situations, where obstruction of epicardial
coronary arteries could not be demonstrated. To address this apparently contradictory issue, a term of ?myocardial infarction with non-obstructive coronary arteries? or MINOCA has been introduced. In recent
years, the number of publications on MINOCA has been steadily growing but the aetiology, epidemiology, predictors and prognosis of MINOCA have not yet been elucidated.
MINOCA occurs in 5-10% of all patients with AMI and these patients are younger and more often females compared to patients with AMI and obstructive CAD and seem to have a better prognosis than patients with
AMI with obstructive CAD.
In this project, we plan to explore the incidence, correlates, and long-term consequences of myocardial injury and coronary events without obstructive coronary arteries in a large population-based cohort. Specifically, we aim to identify coronary events where invasive coronary procedures were not performed (CABG/PCI), focusing primarily on the period after 2000 when PCI became a standard procedure for all ST-elevation and non-ST elevation MIs.
Effective start/end date2020/09/01 → …

UKÄ subject classification

  • Cardiac and Cardiovascular Systems