Natriuretic peptides as targets for heart failure therapy

Heart failure is a leading cause of hospitalization and mortality globally. The natriuretic peptide system is activated in response to increased cardiac filling pressures and reduces cardiac work load through reducing blood volume and pressure. Augmentation of this physiological response could constitute a new therapeutic strategy in heart failure. The aim of this research program is to assess the benefit of RNA-based therapy for natriuretic peptide augmentation in an animal model of heart failure and to study the regulation of natriuretic peptide expression in the human failing heart using single cell and spatial transcriptomics.