Structural analysis of superantigen binding to human receptor

  • Uzuncayir, Sibel (Researcher)

Project: Dissertation

Project Details

Description

Superantigens are bacterial toxins that bind to the T cell receptor and cause massive T cell activation and cytokine production, leading to food poisoning and toxic shock syndrome. Recently, we discovered that superantigens also can bind directly to the signalling domain of human cytokine receptors. The biological outcome of this interaction is yet to be discovered.
To resolve the structural details of the complex, we have performed X-ray crystallography, mass spectrometry cross-linking (MS-XL) analysis to identify crucial residues for the complex formation and we have investigated the binding affinity applying surface plasmon resonance (SPR).
StatusFinished
Effective start/end date2017/11/012022/04/28

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being