Project Details
Description
According to the literature, type1- and type2-diabetes negatively impact on the auditory and vestibular organs of the inner ear. Although several theories have been proposed, the exact underlying mechanisms responsible for diabetes-induced damage remain uncertain. Our hypothesis is that the inner ear is a direct target for insulin action and thus that inner ear insulin resistance could contribute to inner ear dysfunction in diabetes.
| Status | Active |
|---|---|
| Effective start/end date | 2020/01/01 → 2027/12/31 |
Funding
- Diabetesfonden - Stiftelsen Svenska Diabetesförbundets Forskningsfond
- Diabetes Wellness Network Sweden, Insamlingsstiftelsen
- Dir Albert Påhlssons stiftelse för forskning och välgörenhet
- Novo Nordisk Foundation
- Swedish Research Council
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Subject classification (UKÄ)
- Endocrinology and Diabetes
Research output
- 2 Article
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Insulin regulates Nedd4-2 via a PKB-dependent mechanism in HEI-OC1 auditory cells-crosstalks with sphingolipid and cAMP signaling
Pålbrink, A.-K., Morén, B., Stenkula, K. G., Magnusson, M. & Degerman, E., 2022, In: Acta Oto-Laryngologica. 142, 1, p. 6-12 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells
Pålbrink, A.-K., Kopietz, F., Morén, B., In 't Zandt, R., Kalinec, F., Stenkula, K., Göransson, O., Holm, C., Magnusson, M. & Degerman, E., 2020 Mar 31, In: BMJ open diabetes research & care. 8, e000820.Research output: Contribution to journal › Article › peer-review
Open Access