The SANNI project

Safe analgesia for neonatal intensive care. Newborn infants are undergoing neonatal intensive care during a period of unstable organ function and rapid central nervous growth and development. The pain they experience, but also the analgesic drugs might result in permanent negative consequences. The drugs that are routinely used are produced for and tested in the adult patient population and are used “off-label” in the neonatal population.
The purpose of this project is to develop evidence based analgesic and sedative treatment guidelines for sick newborn infants, taking into account the pharmacokinetic (PK), pharmacodynamic (PD), pharmacogenetic (PG) properties and the PK/PD/PG relation of these drugs used on clinical indication during neonatal intensive care. This is in accordance with the national and international directives, and serves to make it possible to provide sick infants with a safe and “tailor made” pharmacological strategy with optimal and individual dosing in the future.