Research output per year
Research output per year
Project Details
Description
The aim of this thesis work is to investigate the delivery efficiency of RNA-based therapeutics to tumor cells. The main focus will be on characterizing how efficient the delivery from endosomes into the cell cytosol is and identifying key proteins involved in this process. Furthermore, a special focus will be on studying the subcellular distribution of therapeutic RNA to determine how effectively the RNA molecules reach their cytosolic targets.
| Status | Active |
|---|---|
| Effective start/end date | 2022/03/01 → … |
Research output
- 1 Article
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Single-cell quantification and dose-response of cytosolic siRNA delivery
Hedlund, H., Du Rietz, H., Johansson, J. M., Eriksson, H. C., Zedan, W., Huang, L., Wallin, J. & Wittrup, A., 2023 Dec, In: Nature Communications. 14, 1, 1075.Research output: Contribution to journal › Article › peer-review
Open Access
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Mechanism of lipid mediated siRNA delivery
Hedlund, H. (Research student), Wittrup, A. (Supervisor), Nordenfelt, P. (Assistant supervisor) & Swaminathan, V. (Assistant supervisor)
2019/01/15 → …
Project: Dissertation
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Membrane damage and tumor targeted siRNA delivery
Du Rietz, H. (Researcher), Wittrup, A. (Supervisor), Nordenfelt, P. (Assistant supervisor) & Leffler, H. (Assistant supervisor)
2016/09/01 → …
Project: Dissertation
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Delivery of Therapeutic siRNA to Glioblastomas
Wilhelmson-Andén, S. (Researcher), Du Rietz, H. (Researcher), Hedlund, H. (Researcher), Wittrup, A. (PI) & Johansson, J. (Researcher)
2018/11/05 → 2025/04/06
Project: Dissertation