Project Details
Description
The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain
health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include
impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke)
diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming
more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic.
However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and
exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This
consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical
studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This
enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant
toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal
exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to
be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the
art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the
adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations,
traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on
old technology engines. Our project will change this.
health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include
impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke)
diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming
more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic.
However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and
exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This
consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical
studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This
enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant
toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal
exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to
be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the
art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the
adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations,
traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on
old technology engines. Our project will change this.
| Short title | TUBE |
|---|---|
| Status | Finished |
| Effective start/end date | 2019/07/01 → 2023/06/30 |