Understanding conformational fluctuations of proteins

  • Söderhjelm, Pär (Researcher)
  • Bhakat, Soumendranath (Research student)
  • Kulkarni, Mandar (Researcher)

Project Details

Description

In our main research project, we are investigating the interconversion between protein conformations, which is fundamental for the biological function of proteins.
The main focus is on developing enhanced-sampling methods that can systematically find important conformations, calculate their relative free energies, and calculate the transition rates between them. We also refine procedures for validating the results towards experimental data, such as hydrogen exchange rates and ring-flipping rate constants.
StatusFinished
Effective start/end date2018/01/012021/12/31

Funding

  • Swedish Research Council