Validation of a new antidiabetic food concept targeting the gut microbiota composition

Validation of a novel pro- and synbiotic concept based on increasing the abundance of gut Prevotella to contribute to prevention of type 2
diabetes and cardiovascular disease

Obesity and type 2 diabetes can to a large extent be prevented. In this context the diet is an important tool, which provides a strong incitement for development of food concepts with antidiabetic properties. In this project we intend to explore an unique antidiabetic food concept with beneficial effects on blood glucose regulation in an over-day perspective, i.e. up to 14 h after consumption. The concept is based on stimulation of a specific gut bacteria via the provision of an optimized matrix of non-digestible carbohydrates (prebiotic foods), alternatively via the supply of the said gut bacteria (probiotic food). The concept has been validated in studies on mice regarding the probiotic potential, and in studies on healthy subjects regarding the prebiotic health effects. In the present project, the concept is further developed through product/process development and validation of effects on blood glucose regulation.