γ-Tubulin⁻γ-Tubulin Interactions as the Basis for the Formation of a Meshwork

Catalina Ana Rosselló, Lisa Lindström, Greta Eklund, Matthieu Corvaisier, Maria Alvarado Kristensson

Research output: Contribution to journalReview articlepeer-review

10 Citations (SciVal)

Abstract

In cytoplasm, protein γ-tubulin joins with various γ-tubulin complex proteins (GCPs) to form a heterotetramer γ-tubulin small complex (γ-TuSC) that can grow into a ring-shaped structure called the γ-tubulin ring complex (γ-TuRC). Both γ-TuSC and γ-TuRC are required for microtubule nucleation. Recent knowledge on γ-tubulin with regard to its cellular functions beyond participation in its creation of microtubules suggests that this protein forms a cellular meshwork. The present review summarizes the recognized functions of γ-tubulin and aims to unite the current views on this protein.

Original languageEnglish
Article number3245
JournalInternational Journal of Molecular Sciences
Volume19
Issue number10
DOIs
Publication statusPublished - 2018 Oct 19

Subject classification (UKÄ)

  • Cell and Molecular Biology

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