3,4-dideoxyglucosone-3-ene in peritoneal dialysis fluids infused into the peritoneal cavity cannot be found in plasma.

Martin Erixon, Anders Wieslander, Torbjörn Lindén, Ola Carlsson, Jan Åke Jönsson, Ole Simonsen, Per Kjellstrand

Research output: Contribution to journalArticlepeer-review

10 Citations (SciVal)

Abstract

OBJECTIVE: Glucose degradation products (GDPs) are important for the outcome of peritoneal dialysis (PD) treatment. The most cytotoxic GDP found in conventionally manufactured fluids, 3,4-dideoxyglucosone-3-ene (3,4-DGE), may in addition be recruited from 3-deoxyglucosone (3-DG). What happens with the GDPs in the fluid infused into patients during PD is not known. We investigated whether 3,4-DGE and 3-DG in PD fluid can be found in plasma during treatment. DESIGN: Patients on PD were dialyzed with a conventional PD fluid containing 43 micromol/L 3,4-DGE and 281 micromol/L 3-DG. Parallel experiments were performed in rats and in vitro with human plasma. The rats were dialyzed with a PD fluid containing 100 micromol/L 3,4-DGE and 200 micromol/L 3-DG. RESULTS: The 3,4-DGE concentration in the peritoneum declined at a much higher rate during the dwell than did the 3-DG concentration. However, 3,4-DGE was not detected in the plasma of patients or of rats during dialysis. The 3-DG concentration in plasma peaked shortly after infusion of fluid into the peritoneal cavity. The 3,4-DGE concentration during experimental incubation in plasma declined rapidly; the 3-DG concentration declined only 10% as rapidly (or less). CONCLUSION: During dialysis, 3,4-DGE could not be detected in plasma of either PD patients or rats, presumably because of its high reactivity. On the other hand, 3-DG may pass through the membrane and be detected in the blood.
Original languageEnglish
Pages (from-to)S28-S31
JournalPeritoneal Dialysis International
Volume29 Suppl 2
Publication statusPublished - 2009
Event12th Congress of the International-Society-for-Peritoneal-Dialysis - Istanbul, TURKEY
Duration: 2008 Jun 202008 Jun 24

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Nephrology (013230024), Analytical Chemistry (S/LTH) (011001004)

Subject classification (UKÄ)

  • Urology and Nephrology

Keywords

  • Peritoneal dialysis fluid
  • glucose degradation products
  • 3
  • 3-DG
  • 4-DGE
  • plasma
  • advanced glycation end-products

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