5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors

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19 Citations (SciVal)

Abstract

Serotonergic receptors were classified in the isolated human uterine artery with intact endothelium, using agonists and antagonists for 5-hydroxytryptamine (5-HT) receptors. The efficacy for different agonists rated: alpha-methyl-5-HT (5-HT2) = 5-HT (non-selective) = 2-methyl-5-HT (5-HT3) >> sumatriptan (5-HT1), and the potency as: sumatriptan = 5-HT > 5-HT > alpha-methyl-5-HT > 2-methyl-5-HT. The contractile effects of 5-HT and alpha-methyl-5-HT were antagonized by the 5-HT2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. The efficacy of sumatriptan was comparatively low. No interaction was encountered between 2-methyl-5-HT and MDL72222, suggesting an absence of 5-HT3 receptors. The results indicate that the contractile serotonergic receptor population in the human uterine artery mainly comprises 5-HT2 receptors, although a minor contribution of contractile 5-HT1 receptors cannot be excluded.
Original languageEnglish
Pages (from-to)361-367
JournalHuman Reproduction
Volume12
Issue number2
Publication statusPublished - 1997

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Preventive Paediatrics (013243030), Division of Infection Medicine (BMC) (013024020), Research Unit for Urogynaecology and Reproductive Pharmacology (013242710)

Subject classification (UKÄ)

  • Obstetrics, Gynecology and Reproductive Medicine
  • Infectious Medicine
  • Pediatrics
  • Clinical Medicine

Keywords

  • 5-HT (5-hydroxytryptamine
  • serotonin)/5-HT properties and linked second messenger systems
  • the 5-HT receptors/smooth muscle/uterine artery (human)

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