Abstract
Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane.
Original language | English |
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Pages (from-to) | 710-716 |
Journal | American Journal of Kidney Diseases |
Volume | 49 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2007 |
Subject classification (UKÄ)
- Urology and Nephrology
Free keywords
- goodpasture disease
- anti-tubular basement membrane antibodies