A 59-kd renal antigen as a new target for rapidly progressive glomerulonephritis

Vincent Audard, Thomas Hellmark, Khalil El Karoui, Laure Helene Noel, Agathe Pardon, Dominique Desvaux, Guy Touchard, Philippe Remy, Philippe Lang, Djillali Sahali

Research output: Contribution to journalArticlepeer-review

Abstract

Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane.
Original languageEnglish
Pages (from-to)710-716
JournalAmerican Journal of Kidney Diseases
Volume49
Issue number5
DOIs
Publication statusPublished - 2007

Subject classification (UKÄ)

  • Urology and Nephrology

Free keywords

  • goodpasture disease
  • anti-tubular basement membrane antibodies

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