TY - JOUR
T1 - A clinical distance measure for evaluating treatment plan quality difference with Pareto fronts in radiotherapy
AU - Petersson, Kristoffer
AU - Kyroudi, Archonteia
AU - Bourhis, Jean
AU - Ceberg, Crister
AU - Knoos, Tommy
AU - Bochud, Francois
AU - Möckli, Raphaël
PY - 2017/7
Y1 - 2017/7
N2 - We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference.
AB - We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r = 0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of >0.32 (0.28–0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference.
U2 - 10.1016/j.phro.2017.09.003
DO - 10.1016/j.phro.2017.09.003
M3 - Article
SN - 2405-6316
VL - 3
SP - 53
EP - 56
JO - Physics and imaging in radiation oncology
JF - Physics and imaging in radiation oncology
ER -