A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

Anna Waldhuber; Greg A Snyder; Franziska Römmler; Christine Cirl; Tina Müller; Tsan Sam Xiao; Catharina Svanborg; Thomas Miethke

doi:10.3390/pathogens5010025

A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

Anna Waldhuber, Greg A Snyder, Franziska Römmler, Christine Cirl, Tina Müller, Tsan Sam Xiao, Catharina Svanborg, Thomas Miethke

Division of Microbiology, Immunology and Glycobiology - MIG

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Abstract

The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.

Original language	English
Pages (from-to)	1-8
Journal	Pathogens
Volume	5
Issue number	25
DOIs	https://doi.org/10.3390/pathogens5010025
Publication status	Published - 2016

Subject classification (UKÄ)

Microbiology in the medical area

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10.3390/pathogens5010025

MDPI_Waldhuber_et_al

http://www.ncbi.nlm.nih.gov/pubmed/26938564?dopt=Abstract

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title = "A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.",

abstract = "The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.",

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T1 - A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

AU - Waldhuber, Anna

AU - Snyder, Greg A

AU - Römmler, Franziska

AU - Cirl, Christine

AU - Müller, Tina

AU - Xiao, Tsan Sam

AU - Svanborg, Catharina

AU - Miethke, Thomas

PY - 2016

Y1 - 2016

N2 - The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.

AB - The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.

U2 - 10.3390/pathogens5010025

DO - 10.3390/pathogens5010025

M3 - Article

C2 - 26938564

SN - 2076-0817

VL - 5

SP - 1

EP - 8

JO - Pathogens

JF - Pathogens

IS - 25

ER -

A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

Abstract

Subject classification (UKÄ)

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