A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis.

Ravi Suppiah, Chetan Mukhtyar, Oliver Flossmann, Federico Alberici, Bo Baslund, Rajbir Batra, Denise Brown, Julia Holle, Zdenka Hruskova, David R W Jayne, Andrew Judge, Mark A Little, Alessandra Palmisano, Coen Stegeman, Vladimir Tesar, Augusto Vaglio, Kerstin Westman, Raashid Luqmani

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65 Citations (SciVal)

Abstract

Objective. Assessment of disease activity in vasculitis can be achieved using the BVAS, a clinical checklist of relevant symptoms, signs and features of active disease. The aim of this study was to revalidate the BVAS version 3 (BVAS v. 3) in a cohort of patients with systemic vasculitis. Methods. A total of 238 patients with vasculitis from seven countries in Europe were evaluated at a single time point. Spearman's correlation coefficients were calculated between BVAS v. 3 scores, vasculitis activity index (VAI), physician's global assessment (PGA), the physician's treatment decision, CRP and the vasculitis damage index (VDI) to demonstrate that the BVAS v. 3 measures disease activity. Results. WG (63%), Churg-Strauss syndrome (9%) and microscopic polyangiitis (9%) were the most common diagnoses. The BVAS v. 3 showed convergent validity with the VAI [ρ = 0.82 (95% CI 0.77, 0.85)], PGA [ρ = 0.85 (95% CI 0.81, 0.88)] and the physician's treatment decision [ρ = 0.54 (95% CI 0.44, 0.62)]. There was little or no correlation between BVAS v. 3 and the CRP level [ρ = 0.18 (95% CI 0.05, 0.30)] or with the VDI [ρ = -0.10 (95% CI 0.22, 0.03)]. The inter-observer reliability was very high with an intra-class correlation coefficient (ICC) of 0.996 (95% CI 0.990, 0.998) for the total BVAS v. 3 score. Conclusion. The BVAS v. 3 has been evaluated in a large cohort of patients with vasculitis and the important properties of the tool revalidated. This study increases the utility of the BVAS v. 3 in different populations of patients with systemic vasculitis.
Original languageEnglish
Pages (from-to)899-905
JournalRheumatology (Oxford, England)
Volume50
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Rheumatology and Autoimmunity

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