A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients

M Loden, AC Andersson, C Anderson, IM Bergbrant, T Frodin, H Ohman, MH Sandstrom, T Sarnhult, E Voog, B Stenberg, E Pawlik, A Preisler-Haggqvist, Åke Svensson, M Lindberg

Research output: Contribution to journalArticlepeer-review

82 Citations (SciVal)

Abstract

Moisturizing creams have beneficial effects in the treatment of dry, scaly skin, but they may induce adverse skin reactions. In a randomized double-blind study, 197 patients with atopic dermatitis were treated with one of the following: a new moisturizing cream with 20% glycerin, its cream base without glycerin as placebo, or a cream with 4% urea and 4% sodium chloride. The patients were asked to apply the cream at least once daily for 30 days. Adverse skin reactions and changes in skin dryness were assessed by the patient and a dermatologist. Adverse skin reactions such as smarting (a sharp local superficial sensation) were felt significantly less among patients using the 20% glycerin cream compared with the urea-saline cream, because 10% of the patients judged the smarting as severe or moderate when using glycerin cream, whereas 24% did so using urea-saline cream (p<0.0006). No differences were found regarding skin reactions such as stinging, itching and dryness/irritation. The study showed equal effects on skin dryness as judged by the patients and the dermatologist. In conclusion, a glycerin containing cream appears to be a suitable alternative to urea/sodium chloride in the treatment of atopic dry skin.
Original languageEnglish
Pages (from-to)45-47
JournalActa Dermato-Venereologica
Volume82
Issue number1
DOIs
Publication statusPublished - 2002

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Department of Dermatology and Venereology (Lund) (013006000)

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases

Keywords

  • emollients
  • cream
  • dry skin
  • moisturizer

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