Abstract
Surrogate markers for reverse cholesterol transport (RCT) efficiency such as HDL cholesterol and immune methods for apolipoprotein A-I (ApoA-I) may not fully reflect the actual efficiency of the RCT pathway. Several genetic variants and different posttranslational proteoforms of ApoA-I may unevenly affect the functionality of the HDL particle to efflux cholesterol. A method employing top-down immunoaffinity LC-MS of ApoA-I in order to characterize the most prevalent ApoA-I proteoforms in human plasma is described.
Original language | English |
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Pages (from-to) | 87-95 |
Journal | Clinica Chimica Acta |
Volume | 442 |
Issue number | Jan 17 |
DOIs | |
Publication status | Published - 2015 |
Subject classification (UKÄ)
- Clinical Laboratory Medicine