TY - JOUR
T1 - A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
AU - Speedy, Helen E
AU - Di Bernardo, Maria Chiara
AU - Sava, Georgina P
AU - Dyer, Martin J S
AU - Holroyd, Amy
AU - Wang, Yufei
AU - Sunter, Nicola J
AU - Mansouri, Larry
AU - Juliusson, Gunnar
AU - Smedby, Karin E
AU - Roos, Göran
AU - Jayne, Sandrine
AU - Majid, Aneela
AU - Dearden, Claire
AU - Hall, Andrew G
AU - Mainou-Fowler, Tryfonia
AU - Jackson, Graham H
AU - Summerfield, Geoffrey
AU - Harris, Robert J
AU - Pettitt, Andrew R
AU - Allsup, David J
AU - Bailey, James R
AU - Pratt, Guy
AU - Pepper, Chris
AU - Fegan, Chris
AU - Rosenquist, Richard
AU - Catovsky, Daniel
AU - Allan, James M
AU - Houlston, Richard S
PY - 2014
Y1 - 2014
N2 - Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.
AB - Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.
U2 - 10.1038/ng.2843
DO - 10.1038/ng.2843
M3 - Article
C2 - 24292274
SN - 1546-1718
VL - 46
SP - 56
JO - Nature Genetics
JF - Nature Genetics
IS - 1
ER -