A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis

E Akesson; A Oturai; J Berg; S Fredrikson; O Andersen; HF Harbo; M Laaksonen; KM Myhr; HI Nyland; LP Ryder; Magnhild Sandberg Wollheim; PS Sorensen; A Spurkland; A Svejgaard; P Holmans; A Compston; J Hillert; S Sawcer

doi:10.1038/sj.gene.6363866

A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis

E Akesson, A Oturai, J Berg, S Fredrikson, O Andersen, HF Harbo, M Laaksonen, KM Myhr, HI Nyland, LP Ryder, Magnhild Sandberg Wollheim, PS Sorensen, A Spurkland, A Svejgaard, P Holmans, A Compston, J Hillert, S Sawcer

Neurology, Lund

Research output: Contribution to journal › Article › peer-review

Abstract

Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis.

Original language	English
Pages (from-to)	279-285
Journal	Genes and Immunity
Volume	3
Issue number	5
DOIs	https://doi.org/10.1038/sj.gene.6363866
Publication status	Published - 2002

Subject classification (UKÄ)

Neurology

Free keywords

multiple sclerosis
linkage
susceptibility gene

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10.1038/sj.gene.6363866

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Akesson, E., Oturai, A., Berg, J., Fredrikson, S., Andersen, O., Harbo, HF., Laaksonen, M., Myhr, KM., Nyland, HI., Ryder, LP., Sandberg Wollheim, M., Sorensen, PS., Spurkland, A., Svejgaard, A., Holmans, P., Compston, A., Hillert, J., & Sawcer, S. (2002). A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. Genes and Immunity, 3(5), 279-285. https://doi.org/10.1038/sj.gene.6363866

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title = "A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis",

abstract = "Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis.",

keywords = "multiple sclerosis, linkage, susceptibility gene",

author = "E Akesson and A Oturai and J Berg and S Fredrikson and O Andersen and HF Harbo and M Laaksonen and KM Myhr and HI Nyland and LP Ryder and {Sandberg Wollheim}, Magnhild and PS Sorensen and A Spurkland and A Svejgaard and P Holmans and A Compston and J Hillert and S Sawcer",

year = "2002",

doi = "10.1038/sj.gene.6363866",

language = "English",

volume = "3",

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journal = "Genes and Immunity",

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Akesson, E, Oturai, A, Berg, J, Fredrikson, S, Andersen, O, Harbo, HF, Laaksonen, M, Myhr, KM, Nyland, HI, Ryder, LP, Sandberg Wollheim, M, Sorensen, PS, Spurkland, A, Svejgaard, A, Holmans, P, Compston, A, Hillert, J & Sawcer, S 2002, 'A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis', Genes and Immunity, vol. 3, no. 5, pp. 279-285. https://doi.org/10.1038/sj.gene.6363866

TY - JOUR

T1 - A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis

AU - Akesson, E

AU - Oturai, A

AU - Berg, J

AU - Fredrikson, S

AU - Andersen, O

AU - Harbo, HF

AU - Laaksonen, M

AU - Myhr, KM

AU - Nyland, HI

AU - Ryder, LP

AU - Sandberg Wollheim, Magnhild

AU - Sorensen, PS

AU - Spurkland, A

AU - Svejgaard, A

AU - Holmans, P

AU - Compston, A

AU - Hillert, J

AU - Sawcer, S

PY - 2002

Y1 - 2002

N2 - Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis.

AB - Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis.

KW - multiple sclerosis

KW - linkage

KW - susceptibility gene

U2 - 10.1038/sj.gene.6363866

DO - 10.1038/sj.gene.6363866

M3 - Article

SN - 1476-5470

VL - 3

SP - 279

EP - 285

JO - Genes and Immunity

JF - Genes and Immunity

IS - 5

ER -

A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis

Abstract

Subject classification (UKÄ)

Free keywords

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