A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

Giovanni Appendino; Lucia Maxia; Marcelo Bascope; Peter J. Houghton; Gonzalo Sanchez-Duffhues; Eduardo Munoz; Olov Sterner

doi:10.1021/np0600954

A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

Giovanni Appendino, Lucia Maxia, Marcelo Bascope, Peter J. Houghton, Gonzalo Sanchez-Duffhues, Eduardo Munoz, Olov Sterner

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

Abstract

Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.

Original language	English
Pages (from-to)	1101-1104
Journal	Journal of Natural Products
Volume	69
Issue number	7
DOIs	https://doi.org/10.1021/np0600954
Publication status	Published - 2006

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

Subject classification (UKÄ)

Organic Chemistry

Access to Document

10.1021/np0600954

Cite this

@article{0b2c11380d7a42e4975edc60c199adab,

title = "A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida",

abstract = "Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.",

author = "Giovanni Appendino and Lucia Maxia and Marcelo Bascope and Houghton, {Peter J.} and Gonzalo Sanchez-Duffhues and Eduardo Munoz and Olov Sterner",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",

year = "2006",

doi = "10.1021/np0600954",

language = "English",

volume = "69",

pages = "1101--1104",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "The American Chemical Society (ACS)",

number = "7",

}

TY - JOUR

T1 - A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

AU - Appendino, Giovanni

AU - Maxia, Lucia

AU - Bascope, Marcelo

AU - Houghton, Peter J.

AU - Sanchez-Duffhues, Gonzalo

AU - Munoz, Eduardo

AU - Sterner, Olov

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

PY - 2006

Y1 - 2006

N2 - Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.

AB - Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.

U2 - 10.1021/np0600954

DO - 10.1021/np0600954

M3 - Article

C2 - 16872156

SN - 0163-3864

VL - 69

SP - 1101

EP - 1104

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 7

ER -

A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

Abstract

Bibliographical note

Subject classification (UKÄ)

Access to Document

Fingerprint

Cite this