A new heteropentanuclear complex containing the [Fe2                             IIIZn3                             II(μ-OH)3] structural motif as a model for purple acid phosphatases

Filipy Gobbo Maranha; Graciela Aparecida dos Santos Silva; Adailton J. Bortoluzzi; Ebbe Nordlander; Rosely A. Peralta; Ademir Neves

doi:10.1016/j.ica.2019.119280

A new heteropentanuclear complex containing the [Fe₂ ^IIIZn₃ ^II(μ-OH)₃] structural motif as a model for purple acid phosphatases

Filipy Gobbo Maranha, Graciela Aparecida dos Santos Silva, Adailton J. Bortoluzzi, Ebbe Nordlander, Rosely A. Peralta, Ademir Neves

Chemical Physics

Federal University of Santa Catarina

Research output: Contribution to journal › Article › peer-review

Abstract

Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe₂ ^IIIZn₃ ^II(μ-OH)₃] structural unit and the unsymmetrical ligand H₂L²-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [Fe^III(μ-OH)Zn^II(L²-et)] unit that is connected to a second dinuclear [Fe^III(μ-OH)Zn^II(L²-et)] unit through a hydroxo bridge while a third Zn^II ion is coordinated by the pendant 1,2-ethanediamine groups of H₂L²-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear Fe^IIIZn^II complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.

Original language	English
Article number	119280
Journal	Inorganica Chimica Acta
DOIs	https://doi.org/10.1016/j.ica.2019.119280
Publication status	Published - 2019 Nov 13

Subject classification (UKÄ)

Inorganic Chemistry

Free keywords

Diesterase
Hydrolase
Pentanuclear complex

Access to Document

10.1016/j.ica.2019.119280

Cite this

Maranha, F. G., dos Santos Silva, G. A., Bortoluzzi, A. J., Nordlander, E., Peralta, R. A., & Neves, A. (2019). A new heteropentanuclear complex containing the [Fe₂ ^IIIZn₃ ^II(μ-OH)₃] structural motif as a model for purple acid phosphatases. Inorganica Chimica Acta, Article 119280. https://doi.org/10.1016/j.ica.2019.119280

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title = "A new heteropentanuclear complex containing the [Fe2 IIIZn3 II(μ-OH)3] structural motif as a model for purple acid phosphatases",

abstract = "Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear FeIIIZnII complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.",

keywords = "Diesterase, Hydrolase, Pentanuclear complex",

author = "Maranha, \{Filipy Gobbo\} and \{dos Santos Silva\}, \{Graciela Aparecida\} and Bortoluzzi, \{Adailton J.\} and Ebbe Nordlander and Peralta, \{Rosely A.\} and Ademir Neves",

year = "2019",

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day = "13",

doi = "10.1016/j.ica.2019.119280",

language = "English",

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A new heteropentanuclear complex containing the [Fe₂ ^IIIZn₃ ^II(μ-OH)₃] structural motif as a model for purple acid phosphatases. / Maranha, Filipy Gobbo; dos Santos Silva, Graciela Aparecida; Bortoluzzi, Adailton J. et al.
In: Inorganica Chimica Acta, 13.11.2019.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A new heteropentanuclear complex containing the [Fe2 IIIZn3 II(μ-OH)3] structural motif as a model for purple acid phosphatases

AU - Maranha, Filipy Gobbo

AU - dos Santos Silva, Graciela Aparecida

AU - Bortoluzzi, Adailton J.

AU - Nordlander, Ebbe

AU - Peralta, Rosely A.

AU - Neves, Ademir

PY - 2019/11/13

Y1 - 2019/11/13

N2 - Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear FeIIIZnII complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.

AB - Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear FeIIIZnII complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.

KW - Diesterase

KW - Hydrolase

KW - Pentanuclear complex

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DO - 10.1016/j.ica.2019.119280

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