A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

Caroline Brorsson; Regine Bergholdt; Marketa Sjögren; Stefanie Eising; Karina Meden Sorensen; David M. Hougaard; Marju Orho-Melander; Leif Groop; Flemming Pociot

doi:10.1016/j.ymgme.2008.02.011

A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

Caroline Brorsson, Regine Bergholdt, Marketa Sjögren, Stefanie Eising, Karina Meden Sorensen, David M. Hougaard, Marju Orho-Melander, Leif Groop, Flemming Pociot

Translational Muscle Research

Research output: Contribution to journal › Article › peer-review

Abstract

Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.

Original language	English
Pages (from-to)	386-388
Journal	Molecular Genetics and Metabolism
Volume	94
Issue number	3
DOIs	https://doi.org/10.1016/j.ymgme.2008.02.011
Publication status	Published - 2008

Subject classification (UKÄ)

Endocrinology and Diabetes

Free keywords

beta-cell function
genetics
type 1 diabetes
SLC30A8
zinc transporter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ymgme.2008.02.011

Cite this

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title = "A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population",

abstract = "Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.",

keywords = "beta-cell function, genetics, type 1 diabetes, SLC30A8, zinc transporter",

author = "Caroline Brorsson and Regine Bergholdt and Marketa Sj{\"o}gren and Stefanie Eising and Sorensen, {Karina Meden} and Hougaard, {David M.} and Marju Orho-Melander and Leif Groop and Flemming Pociot",

year = "2008",

doi = "10.1016/j.ymgme.2008.02.011",

language = "English",

volume = "94",

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journal = "Molecular Genetics and Metabolism",

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publisher = "Elsevier",

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TY - JOUR

T1 - A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

AU - Brorsson, Caroline

AU - Bergholdt, Regine

AU - Sjögren, Marketa

AU - Eising, Stefanie

AU - Sorensen, Karina Meden

AU - Hougaard, David M.

AU - Orho-Melander, Marju

AU - Groop, Leif

AU - Pociot, Flemming

PY - 2008

Y1 - 2008

N2 - Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.

AB - Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.

KW - beta-cell function

KW - genetics

KW - type 1 diabetes

KW - SLC30A8

KW - zinc transporter

U2 - 10.1016/j.ymgme.2008.02.011

DO - 10.1016/j.ymgme.2008.02.011

M3 - Article

SN - 1096-7192

VL - 94

SP - 386

EP - 388

JO - Molecular Genetics and Metabolism

JF - Molecular Genetics and Metabolism

IS - 3

ER -

A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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