A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

Thomas Breslin; Jason Paino; Marie Wegner; Elette Engels; Stefan Fiedler; Helen Forrester; Hannes Rennau; John Bustillo; Matthew Cameron; Daniel Häusermann; Christopher Hall; Dieter Krause; Guido Hildebrandt; Michael Lerch; Elisabeth Schültke

doi:10.3390/biomimetics8020230

A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

Thomas Breslin, Jason Paino, Marie Wegner, Elette Engels, Stefan Fiedler, Helen Forrester, Hannes Rennau, John Bustillo, Matthew Cameron, Daniel Häusermann, Christopher Hall, Dieter Krause, Guido Hildebrandt, Michael Lerch, Elisabeth Schültke

Research output: Contribution to journal › Article › peer-review

Abstract

The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

Original language	English
Article number	230
Journal	Biomimetics
Volume	8
Issue number	2
DOIs	https://doi.org/10.3390/biomimetics8020230
Publication status	Published - 2023

Subject classification (UKÄ)

Radiology, Nuclear Medicine and Medical Imaging

Free keywords

anthropomorphic phantom
CT scan
dosimetry
experimental radiotherapy
microbeam radiotherapy (MRT)
therapy planning
tissue-equivalent materials

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10.3390/biomimetics8020230

Cite this

Breslin, T., Paino, J., Wegner, M., Engels, E., Fiedler, S., Forrester, H., Rennau, H., Bustillo, J., Cameron, M., Häusermann, D., Hall, C., Krause, D., Hildebrandt, G., Lerch, M., & Schültke, E. (2023). A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study. Biomimetics, 8(2), Article 230. https://doi.org/10.3390/biomimetics8020230

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title = "A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study",

abstract = "The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.",

keywords = "anthropomorphic phantom, CT scan, dosimetry, experimental radiotherapy, microbeam radiotherapy (MRT), therapy planning, tissue-equivalent materials",

author = "Thomas Breslin and Jason Paino and Marie Wegner and Elette Engels and Stefan Fiedler and Helen Forrester and Hannes Rennau and John Bustillo and Matthew Cameron and Daniel H{\"a}usermann and Christopher Hall and Dieter Krause and Guido Hildebrandt and Michael Lerch and Elisabeth Sch{\"u}ltke",

year = "2023",

doi = "10.3390/biomimetics8020230",

language = "English",

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Breslin, T, Paino, J, Wegner, M, Engels, E, Fiedler, S, Forrester, H, Rennau, H, Bustillo, J, Cameron, M, Häusermann, D, Hall, C, Krause, D, Hildebrandt, G, Lerch, M & Schültke, E 2023, 'A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study', Biomimetics, vol. 8, no. 2, 230. https://doi.org/10.3390/biomimetics8020230

TY - JOUR

T1 - A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy

T2 - Design, Dosimetry and Biological Pilot Study

AU - Breslin, Thomas

AU - Paino, Jason

AU - Wegner, Marie

AU - Engels, Elette

AU - Fiedler, Stefan

AU - Forrester, Helen

AU - Rennau, Hannes

AU - Bustillo, John

AU - Cameron, Matthew

AU - Häusermann, Daniel

AU - Hall, Christopher

AU - Krause, Dieter

AU - Hildebrandt, Guido

AU - Lerch, Michael

AU - Schültke, Elisabeth

PY - 2023

Y1 - 2023

N2 - The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

AB - The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

KW - anthropomorphic phantom

KW - CT scan

KW - dosimetry

KW - experimental radiotherapy

KW - microbeam radiotherapy (MRT)

KW - therapy planning

KW - tissue-equivalent materials

U2 - 10.3390/biomimetics8020230

DO - 10.3390/biomimetics8020230

M3 - Article

C2 - 37366825

AN - SCOPUS:85163844776

SN - 2313-7673

VL - 8

JO - Biomimetics

JF - Biomimetics

IS - 2

M1 - 230

ER -

A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

Abstract

Subject classification (UKÄ)

Free keywords

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