Projects per year
The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P. acnes in oxic conditions and for skin colonization of P. acnes ex vivo. Taken together, our study strongly suggests that RoxP facilitates P. acnes' survival on human skin, and is an important beneficial factor for the host-commensal interaction. Thus, RoxP is the first described skin microbiota-derived mutualistic factor that potentially can be exploited for human skin protection.
Subject classification (UKÄ)
- Microbiology in the medical area
FingerprintDive into the research topics of 'A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes'. Together they form a unique fingerprint.
- 1 Active
Stiftelsen Sigurd och Elsa Goljes Minne, Åke Wibergs stiftelse, Crafoord Foundation, Stiftelsen Lars Hiertas minne, Stiftelsen Thelma Zoegas fond för medicinsk forskning, Alfred Österlunds stiftelse, Stiftelsen Tornspiran, The Royal Physiographic Society in Lund, Sven och Dagmar Saléns stiftelse, Magnus Bergvalls Stiftelse, Stiftelsen Längmanska kulturfonden, Stiftelsen Professor Nanna Svartz fond, Swedish Society of Medicine
2015/01/01 → …