A novel fusion 5 ' AFF3/3 ' BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma

L. Impera, F. Albano, C. Lo Cunsolo, S. Funes, P. Iuzzolino, F. Laveder, Ioannis Panagopoulos, M. Rocchi, C. T. Storlazzi

Research output: Contribution to journalArticlepeer-review

Abstract

Follicular lymphoma is the second most frequent type of non-Hodgkin's lymphoma in adults. The basic molecular defect consists of the t(14;18)(q32;q21) translocation, juxtaposing the B-cell lymphoma protein 2 gene BCL2 to the immunoglobulin heavy chain locus IGH@, and leading to the antiapoptotic BCL2 protein overproduction. Variations in the t(14;18) are rare and can be classified into two categories: (i) simple variants, involving chromosomes 18 and 2, or 22, in which the fusion partner of BCL2 is the light-chain IGK@ or IGL@; (ii) complex variant translocations occurring among chromosomes 14, 18 and other chromosomes. We report a follicular lymphoma case showing BCL2 overexpression, detected by immunohistochemistry and real-time quantitative PCR, consequently to the formation of a novel fusion gene between the 5' of the lymphoid nuclear transcriptional activator gene AFF3 at 2q11.2, and the 3' of BCL2. This case shows evidence, for the first time, of BCL2 overexpression consequently to the fusion of BCL2 to a non-IG partner locus.
Original languageEnglish
Pages (from-to)6187-6190
JournalOncogene
Volume27
Issue number47
DOIs
Publication statusPublished - 2008

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • translocation
  • follicular lymphoma
  • fusion gene
  • AFF3
  • BCL2

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