A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia

Vladimir Lj Lazarevic; Dragica Tomin; Gradimir M Jankovic; Darko Antic; Marija Dencic; Mirjana Gotic; Darinka Boskovic

doi:10.1016/S0165-4608(03)00215-2

A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia

Vladimir Lj Lazarevic, Dragica Tomin, Gradimir M Jankovic, Darko Antic, Marija Dencic, Mirjana Gotic, Darinka Boskovic

Norrland University Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.

Original language	English
Pages (from-to)	77-9
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	148
Issue number	1
DOIs	https://doi.org/10.1016/S0165-4608(03)00215-2
Publication status	Published - 2004 Jan 1
Externally published	Yes

Free keywords

Aged
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 2
Humans
Leukemia, Myeloid, Acute
Male
Thrombocythemia, Essential
Translocation, Genetic

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10.1016/S0165-4608(03)00215-2

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title = "A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia",

abstract = "A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1\%-4.5\% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.",

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AU - Lazarevic, Vladimir Lj

AU - Tomin, Dragica

AU - Jankovic, Gradimir M

AU - Antic, Darko

AU - Dencic, Marija

AU - Gotic, Mirjana

AU - Boskovic, Darinka

PY - 2004/1/1

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AB - A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.

KW - Aged

KW - Chromosomes, Human, Pair 17

KW - Chromosomes, Human, Pair 2

KW - Humans

KW - Leukemia, Myeloid, Acute

KW - Male

KW - Thrombocythemia, Essential

KW - Translocation, Genetic

UR - https://www.scopus.com/pages/publications/0347511684

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JO - Cancer Genetics and Cytogenetics

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ER -

A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia

Abstract

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