A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.

Cecilia Svedman; Malin Engfeldt; Anne Marie Api; Valerie T Politano; Donald V Belsito; Marléne Isaksson; Magnus Bruze

doi:10.1111/j.1600-0536.2011.02041.x

A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.

Cecilia Svedman, Malin Engfeldt, Anne Marie Api, Valerie T Politano, Donald V Belsito, Marléne Isaksson, Magnus Bruze

Occupational and Environmental Dermatology

Research output: Contribution to journal › Article › peer-review

Abstract

Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.

Original language	English
Pages (from-to)	137-139
Journal	Contact Dermatitis
Volume	66
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0536.2011.02041.x
Publication status	Published - 2012

Subject classification (UKÄ)

Dermatology and Venereal Diseases

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10.1111/j.1600-0536.2011.02041.x

http://www.ncbi.nlm.nih.gov/pubmed/22320668?dopt=Abstract

Cite this

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title = "A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.",

abstract = "Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.",

author = "Cecilia Svedman and Malin Engfeldt and Api, \{Anne Marie\} and Politano, \{Valerie T\} and Belsito, \{Donald V\} and Marl{\'e}ne Isaksson and Magnus Bruze",

year = "2012",

doi = "10.1111/j.1600-0536.2011.02041.x",

language = "English",

volume = "66",

pages = "137--139",

journal = "Contact Dermatitis",

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TY - JOUR

T1 - A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.

AU - Svedman, Cecilia

AU - Engfeldt, Malin

AU - Api, Anne Marie

AU - Politano, Valerie T

AU - Belsito, Donald V

AU - Isaksson, Marléne

AU - Bruze, Magnus

PY - 2012

Y1 - 2012

N2 - Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.

AB - Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.

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DO - 10.1111/j.1600-0536.2011.02041.x

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SN - 0105-1873

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ER -

A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.

Abstract

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