A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias

Emma L. Jones; Dag Aarsland; Elisabet Londos; Clive Ballard

doi:10.1159/000334759

A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias

Emma L. Jones, Dag Aarsland, Elisabet Londos, Clive Ballard

Research output: Contribution to journal › Article › peer-review

Abstract

Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia. Copyright (C) 2012 S. Karger AG, Basel

Original language	English
Pages (from-to)	229-231
Journal	Neurodegenerative Diseases
Volume	10
Issue number	1-4
DOIs	https://doi.org/10.1159/000334759
Publication status	Published - 2012

Subject classification (UKÄ)

Neurology

Free keywords

Dementia with Lewy bodies
Parkinson's disease
Genetic association
alpha-Synuclein
DYRK1A

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10.1159/000334759

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title = "A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias",

abstract = "Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia. Copyright (C) 2012 S. Karger AG, Basel",

keywords = "Dementia with Lewy bodies, Parkinson's disease, Genetic association, alpha-Synuclein, DYRK1A",

author = "Jones, {Emma L.} and Dag Aarsland and Elisabet Londos and Clive Ballard",

year = "2012",

doi = "10.1159/000334759",

language = "English",

volume = "10",

pages = "229--231",

journal = "Neurodegenerative Diseases",

issn = "1660-2862",

publisher = "Karger",

number = "1-4",

}

TY - JOUR

T1 - A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias

AU - Jones, Emma L.

AU - Aarsland, Dag

AU - Londos, Elisabet

AU - Ballard, Clive

PY - 2012

Y1 - 2012

N2 - Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia. Copyright (C) 2012 S. Karger AG, Basel

AB - Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia. Copyright (C) 2012 S. Karger AG, Basel

KW - Dementia with Lewy bodies

KW - Parkinson's disease

KW - Genetic association

KW - alpha-Synuclein

KW - DYRK1A

U2 - 10.1159/000334759

DO - 10.1159/000334759

M3 - Article

SN - 1660-2862

VL - 10

SP - 229

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JO - Neurodegenerative Diseases

JF - Neurodegenerative Diseases

IS - 1-4

ER -

A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias

Abstract

Subject classification (UKÄ)

Free keywords

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