A polymer neural probe with tunable flexibility

Fredrik Ejserholm; A. Vastesson; T. Haraldsson; W. van der Wijngaart; J. Schouenborg; Lars Wallman; Martin Bengtsson

doi:10.1109/NER.2013.6696028

A polymer neural probe with tunable flexibility

Fredrik Ejserholm, A. Vastesson, T. Haraldsson, W. van der Wijngaart, J. Schouenborg, Lars Wallman, Martin Bengtsson

Division for Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

Abstract

A novel polymeric material, off-stoichiometry thiol-ene-epoxy (OSTE+), has been evaluated for the fabrication of neural implants. OSTE+ is easily photo-structurable and exhibits mechanical properties suitable for stable implantation of the probe into brain tissue, while being sufficiently soft at physiological temperatures to reduce living tissue damage. The facile processing of OSTE+ allows use in applications where SU-8 or polyimide currently are the materials of choice. Uniquely, OSTE+ has a Young's modulus of 1.9 GPa at 10 degrees C decreasing almost two orders of magnitude to 30 MPa at 40 degrees C, which can be compared to the Young's modulus of 2.1 GPa for SU-8. We show a probe, with nine gold electrode sites, implanted into 0.5% agar at 40 degrees C using active cooling during the implantation.

Original language	English
Title of host publication	2013 6th International IEEE/Embs Conference on Neural Engineering (NER)
Publisher	IEEE - Institute of Electrical and Electronics Engineers Inc.
Pages	691-694
DOIs	https://doi.org/10.1109/NER.2013.6696028
Publication status	Published - 2013
Event	6th International IEEE EMBS Conference on Neural Engineering (NER) - San Diego, CA Duration: 2013 Nov 6 → 2013 Nov 8

Publication series

Name
ISSN (Print)	1948-3546

Conference

Conference	6th International IEEE EMBS Conference on Neural Engineering (NER)
Period	2013/11/06 → 2013/11/08

Subject classification (UKÄ)

Medical Engineering

Access to Document

10.1109/NER.2013.6696028

Cite this

@inproceedings{108242c86d9740269909db7a3f0e2ec1,

title = "A polymer neural probe with tunable flexibility",

abstract = "A novel polymeric material, off-stoichiometry thiol-ene-epoxy (OSTE+), has been evaluated for the fabrication of neural implants. OSTE+ is easily photo-structurable and exhibits mechanical properties suitable for stable implantation of the probe into brain tissue, while being sufficiently soft at physiological temperatures to reduce living tissue damage. The facile processing of OSTE+ allows use in applications where SU-8 or polyimide currently are the materials of choice. Uniquely, OSTE+ has a Young's modulus of 1.9 GPa at 10 degrees C decreasing almost two orders of magnitude to 30 MPa at 40 degrees C, which can be compared to the Young's modulus of 2.1 GPa for SU-8. We show a probe, with nine gold electrode sites, implanted into 0.5% agar at 40 degrees C using active cooling during the implantation.",

author = "Fredrik Ejserholm and A. Vastesson and T. Haraldsson and {van der Wijngaart}, W. and J. Schouenborg and Lars Wallman and Martin Bengtsson",

year = "2013",

doi = "10.1109/NER.2013.6696028",

language = "English",

publisher = "IEEE - Institute of Electrical and Electronics Engineers Inc.",

pages = "691--694",

booktitle = "2013 6th International IEEE/Embs Conference on Neural Engineering (NER)",

address = "United States",

note = "6th International IEEE EMBS Conference on Neural Engineering (NER) ; Conference date: 06-11-2013 Through 08-11-2013",

}

Ejserholm, F, Vastesson, A, Haraldsson, T, van der Wijngaart, W, Schouenborg, J, Wallman, L & Bengtsson, M 2013, A polymer neural probe with tunable flexibility. in 2013 6th International IEEE/Embs Conference on Neural Engineering (NER). IEEE - Institute of Electrical and Electronics Engineers Inc., pp. 691-694, 6th International IEEE EMBS Conference on Neural Engineering (NER), 2013/11/06. https://doi.org/10.1109/NER.2013.6696028

A polymer neural probe with tunable flexibility. / Ejserholm, Fredrik; Vastesson, A.; Haraldsson, T. et al.
2013 6th International IEEE/Embs Conference on Neural Engineering (NER). IEEE - Institute of Electrical and Electronics Engineers Inc., 2013. p. 691-694.

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

TY - GEN

T1 - A polymer neural probe with tunable flexibility

AU - Ejserholm, Fredrik

AU - Vastesson, A.

AU - Haraldsson, T.

AU - van der Wijngaart, W.

AU - Schouenborg, J.

AU - Wallman, Lars

AU - Bengtsson, Martin

PY - 2013

Y1 - 2013

N2 - A novel polymeric material, off-stoichiometry thiol-ene-epoxy (OSTE+), has been evaluated for the fabrication of neural implants. OSTE+ is easily photo-structurable and exhibits mechanical properties suitable for stable implantation of the probe into brain tissue, while being sufficiently soft at physiological temperatures to reduce living tissue damage. The facile processing of OSTE+ allows use in applications where SU-8 or polyimide currently are the materials of choice. Uniquely, OSTE+ has a Young's modulus of 1.9 GPa at 10 degrees C decreasing almost two orders of magnitude to 30 MPa at 40 degrees C, which can be compared to the Young's modulus of 2.1 GPa for SU-8. We show a probe, with nine gold electrode sites, implanted into 0.5% agar at 40 degrees C using active cooling during the implantation.

AB - A novel polymeric material, off-stoichiometry thiol-ene-epoxy (OSTE+), has been evaluated for the fabrication of neural implants. OSTE+ is easily photo-structurable and exhibits mechanical properties suitable for stable implantation of the probe into brain tissue, while being sufficiently soft at physiological temperatures to reduce living tissue damage. The facile processing of OSTE+ allows use in applications where SU-8 or polyimide currently are the materials of choice. Uniquely, OSTE+ has a Young's modulus of 1.9 GPa at 10 degrees C decreasing almost two orders of magnitude to 30 MPa at 40 degrees C, which can be compared to the Young's modulus of 2.1 GPa for SU-8. We show a probe, with nine gold electrode sites, implanted into 0.5% agar at 40 degrees C using active cooling during the implantation.

U2 - 10.1109/NER.2013.6696028

DO - 10.1109/NER.2013.6696028

M3 - Paper in conference proceeding

SP - 691

EP - 694

BT - 2013 6th International IEEE/Embs Conference on Neural Engineering (NER)

PB - IEEE - Institute of Electrical and Electronics Engineers Inc.

T2 - 6th International IEEE EMBS Conference on Neural Engineering (NER)

Y2 - 6 November 2013 through 8 November 2013

ER -

A polymer neural probe with tunable flexibility

Abstract

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