TY - JOUR
T1 - A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality.
AU - Bay-Richter, Cecilie
AU - Linderholm, Klas R
AU - Lim, Chai K
AU - Samuelsson, Martin
AU - Träskman Bendz, Lil
AU - Guillemin, Gilles J
AU - Erhardt, Sophie
AU - Brundin, Lena
PY - 2015
Y1 - 2015
N2 - Patients with depression and suicidality suffer from low-grade neuroinflammation. Pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase, an initial enzyme of the kynurenine pathway. This pathway produces neuroactive metabolites, including quinolinic- and kynurenic acid, binding to the glutamate N-methyl-d-aspartate-receptor, which is hypothesized to be part of the neural mechanisms underlying symptoms of depression. We therefore hypothesized that symptoms of depression and suicidality would fluctuate over time in patients prone to suicidal behavior, depending on the degree of inflammation and kynurenine metabolite levels in the cerebrospinal fluid (CSF).
AB - Patients with depression and suicidality suffer from low-grade neuroinflammation. Pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase, an initial enzyme of the kynurenine pathway. This pathway produces neuroactive metabolites, including quinolinic- and kynurenic acid, binding to the glutamate N-methyl-d-aspartate-receptor, which is hypothesized to be part of the neural mechanisms underlying symptoms of depression. We therefore hypothesized that symptoms of depression and suicidality would fluctuate over time in patients prone to suicidal behavior, depending on the degree of inflammation and kynurenine metabolite levels in the cerebrospinal fluid (CSF).
U2 - 10.1016/j.bbi.2014.07.012
DO - 10.1016/j.bbi.2014.07.012
M3 - Article
C2 - 25124710
SN - 1090-2139
VL - 43
SP - 110
EP - 117
JO - Brain Behavior and Immunity
JF - Brain Behavior and Immunity
IS - Aug 12
ER -
