A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate

James C.S. Ho, Ines Ambite, K. H. Mok, Marek Babjuk, Catharina Svanborg

Research output: Contribution to journalArticlepeer-review

Abstract

The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.

Original languageEnglish
JournalMolecular and Cellular Oncology
Volume8
Issue number5
Early online date2021
DOIs
Publication statusPublished - 2021

Subject classification (UKÄ)

  • Microbiology in the medical area

Keywords

  • bladder cancer
  • low toxicity
  • Novel cancer therapy
  • peptide-oleate complex
  • protein folding

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