A sol-gel integrated dual-readout microarray platform for quantification and identification of prostate-specific antigen

S. W. Lee, J. H. Lee, H. G. Kwon, T. Laurell, O. C. Jeong, S. Kim

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

Here, we report a sol-gel integrated affinity microarray for on-chip matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), which enables capture and identification of prostate-specific antigen (PSA) in samples. Protein microarray technologies, which involve miniaturizing spots of capture agents (such as antibody and aptamers) on a solid surface, enable multianalyte sensing and high-throughput analysis of protein-protein and protein-ligand interactions. This technique provides high-sensitivity analysis of biomarkers, as well as molecular profiling, and is thus used in the fields of life science, medicine and proteomics [1]. In clinical application, the high sensitive biomarker analysis enables early diagnosis, and prediction of prognosis and the response to treatment [2,3].

Original languageEnglish
Title of host publicationMHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
PublisherIEEE - Institute of Electrical and Electronics Engineers Inc.
Number of pages2
Volume2018-January
ISBN (Electronic)9781538633144
DOIs
Publication statusPublished - 2018 Feb 28
Event28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017 - Nagoya, Japan
Duration: 2017 Dec 32017 Dec 6

Conference

Conference28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017
Country/TerritoryJapan
CityNagoya
Period2017/12/032017/12/06

Subject classification (UKÄ)

  • Biochemistry and Molecular Biology

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