A Statistical DOI Estimation Algorithm for a SiPM-Based Clinical SPECT Insert

Ilenia DrAdda; Ashley J. Morahan; Marco Carminati; Kjell Erlandsson; Michael Ljungberg; Brian F. Hutton; Carlo Fiorini

doi:10.1109/TRPMS.2022.3140411

A Statistical DOI Estimation Algorithm for a SiPM-Based Clinical SPECT Insert

Ilenia DrAdda, Ashley J. Morahan, Marco Carminati, Kjell Erlandsson, Michael Ljungberg, Brian F. Hutton, Carlo Fiorini

Research output: Contribution to journal › Article › peer-review

Abstract

A prototype clinical brain SPECT insert has been designed for use in simultaneous SPECT/MRI. The system utilises novel slit-slat collimators which, like pinhole collimators, suffers from parallax errors due to the large incident angle of photons. A statistical algorithm has been developed to determine the depth-of-interaction (DOI) with a view to improving image performance. The importance of DOI correction was demonstrated using Monte Carlo simulation. This simulation also indicated that 4 DOI layers (3×1.5 mm+3.5 mm) may be sufficient. The improvement in event localisation was demonstrated on a single detector before implementing the algorithm on the full clinical prototype where some limitations in event localisation in layers close to the readout plane were observed. Nevertheless DOI enabled the rejection of poorly localised events with improved resolution in reconstructed line sources.

Original language	English
Pages (from-to)	771-777
Journal	IEEE Transactions on Radiation and Plasma Medical Sciences
Volume	6
Issue number	7
Early online date	2022
DOIs	https://doi.org/10.1109/TRPMS.2022.3140411
Publication status	Published - 2022

Subject classification (UKÄ)

Radiology and Medical Imaging

Free keywords

Biomedical imaging
Calibration
Collimators
depth-of-interaction
Detectors
event localisation.
Image reconstruction
Plasmas
Single photon emission computed tomography
SPECT

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10.1109/TRPMS.2022.3140411

Cite this

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title = "A Statistical DOI Estimation Algorithm for a SiPM-Based Clinical SPECT Insert",

abstract = "A prototype clinical brain SPECT insert has been designed for use in simultaneous SPECT/MRI. The system utilises novel slit-slat collimators which, like pinhole collimators, suffers from parallax errors due to the large incident angle of photons. A statistical algorithm has been developed to determine the depth-of-interaction (DOI) with a view to improving image performance. The importance of DOI correction was demonstrated using Monte Carlo simulation. This simulation also indicated that 4 DOI layers (3×1.5 mm+3.5 mm) may be sufficient. The improvement in event localisation was demonstrated on a single detector before implementing the algorithm on the full clinical prototype where some limitations in event localisation in layers close to the readout plane were observed. Nevertheless DOI enabled the rejection of poorly localised events with improved resolution in reconstructed line sources.",

keywords = "Biomedical imaging, Calibration, Collimators, depth-of-interaction, Detectors, event localisation., Image reconstruction, Plasmas, Single photon emission computed tomography, SPECT",

author = "Ilenia DrAdda and Morahan, {Ashley J.} and Marco Carminati and Kjell Erlandsson and Michael Ljungberg and Hutton, {Brian F.} and Carlo Fiorini",

year = "2022",

doi = "10.1109/TRPMS.2022.3140411",

language = "English",

volume = "6",

pages = "771--777",

journal = "IEEE Transactions on Radiation and Plasma Medical Sciences",

issn = "2469-7311",

publisher = "IEEE - Institute of Electrical and Electronics Engineers Inc.",

number = "7 ",

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T1 - A Statistical DOI Estimation Algorithm for a SiPM-Based Clinical SPECT Insert

AU - DrAdda, Ilenia

AU - Morahan, Ashley J.

AU - Carminati, Marco

AU - Erlandsson, Kjell

AU - Ljungberg, Michael

AU - Hutton, Brian F.

AU - Fiorini, Carlo

PY - 2022

Y1 - 2022

N2 - A prototype clinical brain SPECT insert has been designed for use in simultaneous SPECT/MRI. The system utilises novel slit-slat collimators which, like pinhole collimators, suffers from parallax errors due to the large incident angle of photons. A statistical algorithm has been developed to determine the depth-of-interaction (DOI) with a view to improving image performance. The importance of DOI correction was demonstrated using Monte Carlo simulation. This simulation also indicated that 4 DOI layers (3×1.5 mm+3.5 mm) may be sufficient. The improvement in event localisation was demonstrated on a single detector before implementing the algorithm on the full clinical prototype where some limitations in event localisation in layers close to the readout plane were observed. Nevertheless DOI enabled the rejection of poorly localised events with improved resolution in reconstructed line sources.

AB - A prototype clinical brain SPECT insert has been designed for use in simultaneous SPECT/MRI. The system utilises novel slit-slat collimators which, like pinhole collimators, suffers from parallax errors due to the large incident angle of photons. A statistical algorithm has been developed to determine the depth-of-interaction (DOI) with a view to improving image performance. The importance of DOI correction was demonstrated using Monte Carlo simulation. This simulation also indicated that 4 DOI layers (3×1.5 mm+3.5 mm) may be sufficient. The improvement in event localisation was demonstrated on a single detector before implementing the algorithm on the full clinical prototype where some limitations in event localisation in layers close to the readout plane were observed. Nevertheless DOI enabled the rejection of poorly localised events with improved resolution in reconstructed line sources.

KW - Biomedical imaging

KW - Calibration

KW - Collimators

KW - depth-of-interaction

KW - Detectors

KW - event localisation.

KW - Image reconstruction

KW - Plasmas

KW - Single photon emission computed tomography

KW - SPECT

U2 - 10.1109/TRPMS.2022.3140411

DO - 10.1109/TRPMS.2022.3140411

M3 - Article

AN - SCOPUS:85122572817

SN - 2469-7311

VL - 6

SP - 771

EP - 777

JO - IEEE Transactions on Radiation and Plasma Medical Sciences

JF - IEEE Transactions on Radiation and Plasma Medical Sciences

IS - 7

ER -

A Statistical DOI Estimation Algorithm for a SiPM-Based Clinical SPECT Insert

Abstract

Subject classification (UKÄ)

Free keywords

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