A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries: Different practices of assessment and management

Nadine G. Andersson, Mathias Rathe, Ingolf Mølle, Kirsten Brunswig Jarvis, Marianne Hoffmann, Anu Huurre, Joel Joelsson, Birgitte Klug Albertsen, Olli Lohi, Satu Långström, Ulrik Overgaard, Sonata Saulyte Trakymiene, Kaisa Vepsäläinen, Hartmut Vogt, Susanna Ranta

Research output: Contribution to journalArticlepeer-review

Abstract

Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, no paediatric centre did. Almost all providers performed baseline coagulation studies, but only 59% continued the assessment. Fibrinogen replacement was conducted in 59%, and antithrombin replacement in 28% of the centres. The survey highlights the need for guidelines in the management of coagulopathy during ALL therapy.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalBritish Journal of Haematology
Volume199
Issue number1
DOIs
Publication statusPublished - 2022 Oct

Subject classification (UKÄ)

  • Cancer and Oncology

Keywords

  • ALL
  • antithrombin
  • childhood leukaemia
  • paediatric haemostasis
  • paediatric thrombosis
  • thrombosis

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