A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia

Kristian Soltesz, Klaske van Heusden, Martin Hast, J. Mark Ansermino, Guy A. Dumont

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

244 Downloads (Pure)


This paper presents a convex-optimization-based technique to obtain parameters for a PID feedback controller, used to control the infusion rate of the anesthetic drug propofol. The controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention. The method is demonstrated using a clinically relevant design example. A controller designed using the proposed method is currently scheduled for clinical evaluation.
Original languageEnglish
Title of host publicationProceedings of the 2016 American Control Conference
PublisherIEEE - Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)978-1-4673-8682-1
Publication statusPublished - 2016
EventAmerican Control Conference, 2016 - Boston, United States
Duration: 2016 Jul 62016 Jul 8


ConferenceAmerican Control Conference, 2016
Abbreviated titleACC 2016
Country/TerritoryUnited States

Subject classification (UKÄ)

  • Other Medical Engineering
  • Control Engineering


Dive into the research topics of 'A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia'. Together they form a unique fingerprint.

Cite this