A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia

Kristian Soltesz; Klaske van Heusden; Martin Hast; J. Mark Ansermino; Guy A. Dumont

doi:10.1109/ACC.2016.7526125

A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia

Kristian Soltesz, Klaske van Heusden, Martin Hast, J. Mark Ansermino, Guy A. Dumont

University of British Columbia

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

244 Downloads (Pure)

Abstract

This paper presents a convex-optimization-based technique to obtain parameters for a PID feedback controller, used to control the infusion rate of the anesthetic drug propofol. The controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention. The method is demonstrated using a clinically relevant design example. A controller designed using the proposed method is currently scheduled for clinical evaluation.

Original language	English
Title of host publication	Proceedings of the 2016 American Control Conference
Publisher	IEEE - Institute of Electrical and Electronics Engineers Inc.
Pages	4877-4882
ISBN (Electronic)	978-1-4673-8682-1
DOIs	https://doi.org/10.1109/ACC.2016.7526125
Publication status	Published - 2016
Event	American Control Conference, 2016 - Boston, United States Duration: 2016 Jul 6 → 2016 Jul 8

Conference

Conference	American Control Conference, 2016
Abbreviated title	ACC 2016
Country/Territory	United States
City	Boston
Period	2016/07/06 → 2016/07/08

Subject classification (UKÄ)

Other Medical Engineering
Control Engineering

Access to Document

10.1109/ACC.2016.7526125

soltesz16fAccepted author manuscript, 578 KB

1 Finished

Anesthesia in Closed Loop
Soltesz, K., Troeng, O., Bagge Carlson, F. & Cervin, A.
2011/01/01 → 2020/01/01
Project: Research

1 Research or teaching at external organisation

University of British Columbia
Kristian Soltesz (Visiting researcher)
2015 Apr 17 → 2015 May 3
Activity: Visiting an external institution › Research or teaching at external organisation

Cite this

@inproceedings{35d2acdcc0e04d618a1d8c26bfc97065,

title = "A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia",

abstract = "This paper presents a convex-optimization-based technique to obtain parameters for a PID feedback controller, used to control the infusion rate of the anesthetic drug propofol. The controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention. The method is demonstrated using a clinically relevant design example. A controller designed using the proposed method is currently scheduled for clinical evaluation.",

author = "Kristian Soltesz and {van Heusden}, Klaske and Martin Hast and Ansermino, {J. Mark} and Dumont, {Guy A.}",

year = "2016",

doi = "10.1109/ACC.2016.7526125",

language = "English",

pages = "4877--4882",

booktitle = "Proceedings of the 2016 American Control Conference",

publisher = "IEEE - Institute of Electrical and Electronics Engineers Inc.",

address = "United States",

note = "American Control Conference, 2016, ACC 2016 ; Conference date: 06-07-2016 Through 08-07-2016",

}

Soltesz, K, van Heusden, K, Hast, M, Ansermino, JM & Dumont, GA 2016, A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia. in Proceedings of the 2016 American Control Conference. IEEE - Institute of Electrical and Electronics Engineers Inc., pp. 4877-4882, American Control Conference, 2016, Boston, United States, 2016/07/06. https://doi.org/10.1109/ACC.2016.7526125

A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia. / Soltesz, Kristian; van Heusden, Klaske; Hast, Martin et al.

Proceedings of the 2016 American Control Conference. IEEE - Institute of Electrical and Electronics Engineers Inc., 2016. p. 4877-4882.

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

TY - GEN

T1 - A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia

AU - Soltesz, Kristian

AU - van Heusden, Klaske

AU - Hast, Martin

AU - Ansermino, J. Mark

AU - Dumont, Guy A.

PY - 2016

Y1 - 2016

N2 - This paper presents a convex-optimization-based technique to obtain parameters for a PID feedback controller, used to control the infusion rate of the anesthetic drug propofol. The controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention. The method is demonstrated using a clinically relevant design example. A controller designed using the proposed method is currently scheduled for clinical evaluation.

AB - This paper presents a convex-optimization-based technique to obtain parameters for a PID feedback controller, used to control the infusion rate of the anesthetic drug propofol. The controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention. The method is demonstrated using a clinically relevant design example. A controller designed using the proposed method is currently scheduled for clinical evaluation.

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DO - 10.1109/ACC.2016.7526125

M3 - Paper in conference proceeding

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BT - Proceedings of the 2016 American Control Conference

PB - IEEE - Institute of Electrical and Electronics Engineers Inc.

T2 - American Control Conference, 2016

Y2 - 6 July 2016 through 8 July 2016

ER -

A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia

Abstract

Conference

Subject classification (UKÄ)

Access to Document

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Projects

Anesthesia in Closed Loop

Activities

University of British Columbia

Cite this