A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study

Heidi Marjonen; Minttu Marttila; Teemu Paajanen; Marleena Vornanen; Minna Brunfeldt; Anni Joensuu; Otto Halmesvaara; Kimmo Aro; Mervi Alanne-Kinnunen; Pekka Jousilahti; Katja Borodulin; Seppo Koskinen; Tiinamaija Tuomi; Pirjo Ilanne-Parikka; Jaana Lindström; Merja K. Laine; Kirsi Auro; Helena Kääriäinen; Markus Perola; Kati Kristiansson

doi:10.3389/fgene.2021.763159

A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study

Heidi Marjonen, Minttu Marttila, Teemu Paajanen, Marleena Vornanen, Minna Brunfeldt, Anni Joensuu, Otto Halmesvaara, Kimmo Aro, Mervi Alanne-Kinnunen, Pekka Jousilahti, Katja Borodulin, Seppo Koskinen, Tiinamaija Tuomi, Pirjo Ilanne-Parikka, Jaana Lindström, Merja K. Laine, Kirsi Auro, Helena Kääriäinen, Markus Perola, Kati Kristiansson

Research output: Contribution to journal › Article › peer-review

Abstract

We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.

Original language	English
Article number	763159
Journal	Frontiers in Genetics
Volume	12
DOIs	https://doi.org/10.3389/fgene.2021.763159
Publication status	Published - 2021 Oct 29

Subject classification (UKÄ)

Endocrinology and Diabetes

Free keywords

coronary heart disease
finhealth 2017 study
P5 study
polygenic risk sore
precision population health
type 2 diabetes
venous thromboembolism
web portal

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fgene.2021.763159

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Marjonen, H., Marttila, M., Paajanen, T., Vornanen, M., Brunfeldt, M., Joensuu, A., Halmesvaara, O., Aro, K., Alanne-Kinnunen, M., Jousilahti, P., Borodulin, K., Koskinen, S., Tuomi, T., Ilanne-Parikka, P., Lindström, J., Laine, M. K., Auro, K., Kääriäinen, H., Perola, M., & Kristiansson, K. (2021). A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study. Frontiers in Genetics, 12, Article 763159. https://doi.org/10.3389/fgene.2021.763159

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abstract = "We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person{\textquoteright}s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.",

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author = "Heidi Marjonen and Minttu Marttila and Teemu Paajanen and Marleena Vornanen and Minna Brunfeldt and Anni Joensuu and Otto Halmesvaara and Kimmo Aro and Mervi Alanne-Kinnunen and Pekka Jousilahti and Katja Borodulin and Seppo Koskinen and Tiinamaija Tuomi and Pirjo Ilanne-Parikka and Jaana Lindstr{\"o}m and Laine, {Merja K.} and Kirsi Auro and Helena K{\"a}{\"a}ri{\"a}inen and Markus Perola and Kati Kristiansson",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 Marjonen, Marttila, Paajanen, Vornanen, Brunfeldt, Joensuu, Halmesvaara, Aro, Alanne-Kinnunen, Jousilahti, Borodulin, Koskinen, Tuomi, Ilanne-Parikka, Lindstr{\"o}m, Laine, Auro, K{\"a}{\"a}ri{\"a}inen, Perola and Kristiansson.",

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month = oct,

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doi = "10.3389/fgene.2021.763159",

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Marjonen, H, Marttila, M, Paajanen, T, Vornanen, M, Brunfeldt, M, Joensuu, A, Halmesvaara, O, Aro, K, Alanne-Kinnunen, M, Jousilahti, P, Borodulin, K, Koskinen, S, Tuomi, T, Ilanne-Parikka, P, Lindström, J, Laine, MK, Auro, K, Kääriäinen, H, Perola, M & Kristiansson, K 2021, 'A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study', Frontiers in Genetics, vol. 12, 763159. https://doi.org/10.3389/fgene.2021.763159

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AU - Marjonen, Heidi

AU - Marttila, Minttu

AU - Paajanen, Teemu

AU - Vornanen, Marleena

AU - Brunfeldt, Minna

AU - Joensuu, Anni

AU - Halmesvaara, Otto

AU - Aro, Kimmo

AU - Alanne-Kinnunen, Mervi

AU - Jousilahti, Pekka

AU - Borodulin, Katja

AU - Koskinen, Seppo

AU - Tuomi, Tiinamaija

AU - Ilanne-Parikka, Pirjo

AU - Lindström, Jaana

AU - Laine, Merja K.

AU - Auro, Kirsi

AU - Kääriäinen, Helena

AU - Perola, Markus

AU - Kristiansson, Kati

N1 - Publisher Copyright: Copyright © 2021 Marjonen, Marttila, Paajanen, Vornanen, Brunfeldt, Joensuu, Halmesvaara, Aro, Alanne-Kinnunen, Jousilahti, Borodulin, Koskinen, Tuomi, Ilanne-Parikka, Lindström, Laine, Auro, Kääriäinen, Perola and Kristiansson.

PY - 2021/10/29

Y1 - 2021/10/29

N2 - We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.

AB - We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person’s future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.

KW - coronary heart disease

KW - finhealth 2017 study

KW - P5 study

KW - polygenic risk sore

KW - precision population health

KW - type 2 diabetes

KW - venous thromboembolism

KW - web portal

U2 - 10.3389/fgene.2021.763159

DO - 10.3389/fgene.2021.763159

M3 - Article

C2 - 34777479

AN - SCOPUS:85119034268

SN - 1664-8021

VL - 12

JO - Frontiers in Genetics

JF - Frontiers in Genetics

M1 - 763159

ER -

A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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