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Abstract
Purpose: To compare, absolute cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast MRI (DSC-MRI) and Xe-133 SPECT. Materials and Methods: CBF was measured in 20 healthy volunteers using DSC-MRI at 3T and Xe-133 SPECT. DSC- MRI was accomplished by gradient-echo EPI and CBF was calculated using a time-shift-insenisitive deconvolution algorithm and regional arterial input functions (AIFs). To improve the reproducibility of AIF registration the time integral was rescaled by use, of a venous output function. In the Xe-133 SPECT experiment, Xe-133 gas was inhaled over 8 minutes and CBF was calculated using a biexponential analysis. Results: The average whole-brain CBF estimates obtained by DSC-MRI and Xe- 133 SPECT were 85 +/- 23 mL/(min 100 g) and 40 +/- 8 mL/(min 100 g), respectively (mean +/- SD, n = 20). The linear CBF relationship between the two modalities showed a correlation coefficient of r = 0.76 and was described by the equation CBF(MRI) = 2.4 CBF(Xe) - 7.9 (CBF in units of mL/(min 100 g)). Conclusion: A reasonable positive linear correlation between MRI-based and SPECT-based CBF estimates was observed after AIF time-integral correction. The use of DSC-MRI typically results in overestimated absolute perfusion estimates and the present study indicates that this trend is further enhanced by the use of high magnetic field strength (3T).
Original language | English |
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Pages (from-to) | 913-920 |
Journal | Journal of Magnetic Resonance Imaging |
Volume | 26 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2007 |
Subject classification (UKÄ)
- Radiology, Nuclear Medicine and Medical Imaging
Free keywords
- magnetic
- cerebral blood flow
- dynamic susceptibility contrast
- resonance imaging
- perfusion
- Xe-133SPECT
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Optimisation and Validation of Dynamic Susceptibility Contrast MRI
Knutsson, L. (PI) & Wirestam, R. (PI)
1997/01/01 → …
Project: Research