Accurate T-1 Mapping for Oxygen-Enhanced MRI in the Mouse Lung Using a Segmented Inversion-Recovery Ultrashort Echo-Time Sequence

M. Zurek, E. Johansson, F. Risse, D. Alamidi, Lars E Olsson, P. D. Hockings

Research output: Contribution to journalArticlepeer-review

14 Citations (SciVal)

Abstract

PurposeA segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T-1 mapping of mouse lung in vivo. MethodsNumerical simulations were performed to estimate T-1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented inversion-recovery ultrashort echo-time sequence was compared with the reference technique (inversion-recovery rapid acquisition with refocused echoes). The in vivo experiments were carried out on free-breathing C57 mice (n = 10), breathing first air and then oxygen. ResultsThe simulations demonstrated the high potential of the technique for accurate and precise T-1 assessment. Phantom experiments showed good agreement for T-1 values measured with segmented inversion-recovery ultrashort echo-time and the reference technique. The in vivo experiment demonstrated the utility of the technique in oxygen-enhanced assessment, where small T-1 changes were detected with high precision. ConclusionSegmented inversion-recovery ultrashort echo-time provides accurate, high resolution T-1 mapping of the lung parenchyma. Magn Reson Med 71:2180-2185, 2014. (c) 2013 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)2180-2185
JournalMagnetic Resonance in Medicine
Volume71
Issue number6
DOIs
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • T-1 mapping
  • lung MRI
  • ultrashort echo-time
  • UTE
  • segmented inversion
  • recovery
  • oxygen-enhanced imaging
  • mouse

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