Acoustic focusing of microparticles in two-phase systems - Towards cell enrichment or medium exchange in droplets

Anna Fornell, Håkan N. Jonsson, Johan Nilsson, Maria Tenje

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

We present a method to first laterally position microparticles inside droplets by acoustic forces and then split the droplet into three daughter droplets to achieve a 2+fold enrichment of microparticles inside the center droplet. We show that acoustic forces can be applied to both manipulate polystyrene beads (5 μm) and red blood cells inside droplets. The presented technology opens up for development of droplet operations used for medium exchange and particle concentration in droplet-based cell assays.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1026-1028
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Conference

Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Country/TerritoryKorea, Republic of
CityGyeongju
Period2015/10/252015/10/29

Subject classification (UKÄ)

  • Biomedical Laboratory Science/Technology

Free keywords

  • Droplet microfluidics
  • Integrated acoustics
  • Ultrasound

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