Acoustic Trapping: System Design, Optimization and Applications

Mikael Evander, Linda Johansson, Tobias Lilliehorn, Monica Almqvist, Lars Wallman, Stefan Johansson, Thomas Laurell, Johan Nilsson

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review


Manipulation, separation and trapping of particles and cells are very important tools in today's bioanalytical and medical field. The acoustic no-contact trapping method presented at earlier MSW 2004 provides a flexible platform for performing cell and particle assays in a perfusion-based microsystem. To further develop the system microfabricated glass channels are now used, resulting in shorter fabrication times and a very inert channel material. The fluidic design has been revised to minimise the risks of leaking and hydrodynamic focusing has been incorporated to ensure a high trapping efficiency. A change of piezoelectric materials has resulted in less thermal losses in the material, higher reproducibility and shorter manufacturing time. The trapping force was estimated by calculating the fluid force exerted on a single particle levitated in the standing wave as a reference. The temperature increase due to the losses in the transducer was measured using a fluorescent dye, indicating a maximum temperature increase of 10 degrees Celsius. Live cells have been trapped and shown to be viable while still suspended in the standing wave, thus making it possible to do on-line studies on, for example, drug response of cell populations.
Original languageEnglish
Title of host publicationProceedings of the sixth Micro Structure Workshop
Number of pages1
Publication statusPublished - 2006
EventMicro Structure Workshop 2006 - Västerås, Sweden
Duration: 2006 May 92006 May 10

Publication series



ConferenceMicro Structure Workshop 2006

Subject classification (UKÄ)

  • Medical Engineering


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